The novel begins with a section entitled “Afterward,” which seems to be a farewell note from someone named Ptolemy to someone named Robyn. The events it mentions have no meaning until the end of the story. Ptolemy’s last words before death are contained here. He explains his motive for confronting Alfred, who we will learn killed his great-great-nephew Reggie. Ptolemy expresses regret for all the things he left undone in life; he appreciates the chance to make at least one thing right by avenging Reggie’s murder. He concludes the story of his life by expressing his gratitude and undying love for Robyn.

The story proper begins by introducing Ptolemy Usher Grey. He is a ninety-one-year-old Black man and lives in a rundown apartment in Los Angeles. Although he is physically healthy, he is losing his memory. His mind drifts between past and present and he often confuses people in his current life with others who are gone. His great-great-nephew Reggie often comes by to help him out and take him grocery shopping.

One day, a different relative named Hilly comes knocking at the door. He announces that Reggie’s aunt, Niecie, has sent him to take care of Ptolemy because Reggie can’t.